Evaluation of the effects of commercial Moringa Oleifera supplement on physical fitness of young fit adults A pilot study
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Abstract
Background. The Moringa oleifera (Moringa) nutritional supplement is often used for medicinal purposes due to its acclaimed healing abilities. Indeed, research indicates that Moringa possesses antioxidant and anti-inflammatory properties, and has the potential of being an ergogenic substance by enhancing energy metabolism. Yet, despite numerous manufacturers producing Moringa-based supplements, little scientific research has been conducted on humans. Aims. The aim of this pilot study was to evaluate the effects of Moringa as an ergogenic aid in improving aerobic and anaerobic exercise performance in healthy young fit subjects. Methods. A randomized, double-blind controlled study was performed to evaluate Moringa supplement compared to placebo. The study included 16 healthy young male and female, age 26.6 ± 3.0 years physical education college students. Participants were evaluated before and after six weeks of intervention of Moringa (310 mg x 2) or placebo capsules. Participants were measured for body composition, resting blood pressure (BP), resting heart rate (HR), graded cardiopulmonary test on a treadmill until reaching maximal oxygen consumption (VO2max) and maximal anaerobic Wingate bicycle test. Results. There were no differences in physiological or physical performances between the two groups before and after the intervention. Conclusions. Despite promising indications of positive effects of Moringa plant on physiological processes, there was no effect on physical activity performance. As such, the administering of Moringa for improving athletic performance should be taken with caution. Further studies should be conducted to examine the effects of the Moringa plant on human performance in other populations.
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References
Abdull Razis, A. F., Ibrahim, M. D., & Kntayya, S. B. (2014). Health benefits of Moringa oleifera. Asian Pacific Journal of Cancer Prevention : APJCP, 15(20), 8571-8576. https://doi.org/10.7314/APJCP.2014.15.20.8571 DOI: https://doi.org/10.7314/APJCP.2014.15.20.8571
Adedapo, A. A., Falayi, O. O., & Oyagbemi, A. A. (2015). Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals. Journal of Basic and Clinical Physiology and Pharmacology, 26(5), 491-499. https://doi.org/10.1515/jbcpp-2014-0105 DOI: https://doi.org/10.1515/jbcpp-2014-0105
Ali Redha, A., Perna, S., Riva, A., Petrangolini, G., Peroni, G., Nichetti, M., Iannello, G., Naso, M., Faliva, M. A., & Rondanelli, M. (2021). Novel insights on anti-obesity potential of the miracle tree, Moringa oleifera: A systematic review. Journal of Functional Foods, 84, 104600. https://doi.org/10.1016/j.jff.2021.104600 DOI: https://doi.org/10.1016/j.jff.2021.104600
Alidadi, M., Jamialahmadi, T., Cicero, A. F. G., Bianconi, V., Pirro, M., Banach, M., & Sahebkar, A. (2020). The potential role of plant-derived natural products in improving arterial stiffness: A review of dietary intervention studies. Trends in Food Science & Technology, 99, 426-440. https://doi.org/10.1016/j.tifs.2020.03.026 DOI: https://doi.org/10.1016/j.tifs.2020.03.026
Barodia, K., Cheruku, S. P., Kanwal, A., Menon, A., Rajeevan, R., Rukade, A., Kumar Shenoy, R. U., Prabhu, C., Sharma, V., Divya, K. P., Sumalatha, S., Nayak, Y., & Kumar, N. (2022). Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles. Journal of Ayurveda and Integrative Medicine, 13(1), 100503. https://doi.org/10.1016/j.jaim.2021.07.019 DOI: https://doi.org/10.1016/j.jaim.2021.07.019
Calabrese, E. J. (2021). Hormesis Mediates Acquired Resilience: Using Plant-Derived Chemicals to Enhance Health. Https://Doi.Org/10.1146/Annurev-Food-062420-124437, 12, 355-381. https://doi.org/10.1146/annurev-food-062420-124437 DOI: https://doi.org/10.1146/annurev-food-062420-124437
Duranti, G., Maldini, M., Crognale, D., Sabatini, S., Corana, F., Horner, K., & Ceci, R. (2021). Moringa oleifera leaf extract influences oxidative metabolism in C2C12 myotubes through SIRT1-PPARα pathway. Phytomedicine Plus, 1(1), 100014. https://doi.org/10.1016/j.phyplu.2020.100014 DOI: https://doi.org/10.1016/j.phyplu.2020.100014
Essa, M. M., Memon, M. A., & Akbar, M. (2014). Food and brain health. In Food and Brain Health.
Eze, Siobhan M., (2020). "Moringa oleifera Improves Skeletal Muscle Metabolism and Running Performance in Mice." Dissertation, Georgia State University. https://doi.org/10.57709/17632265
George, G. O., Ajayi, O. B., & Oyemike, A. A. (2018). Effect of Moringa oleifera leaf aqueous extract on intraocular and blood pressure of normotensive adults in Edo State, Nigeria. Journal of the Nigerian Optometric Association, 20(2), 75-81.
Gopi, S., Jacob, J., Varma, K., Amalraj, A., Sreeraj, T. R., Kunnumakkara, A. B., & Divya, C. (2017). Natural sports supplement formulation for physical endurance: a randomized, double-blind, placebo-controlled study. Sport Sciences for Health, 13(1), 183-194. https://doi.org/10.1007/s11332-017-0352-y DOI: https://doi.org/10.1007/s11332-017-0352-y
Gupta, A., Gautam, M. K., Singh, R. K., Kumar, M. V., Rao, C. V, Goel, R. K., & Anupurba, S. (2010). Immunomodulatory effect of moringa oleifera lam. extract on cyclophosphamide induced toxicity in mice. Indian Journal of Experimental Biology, 48(11), 1157-1160.
Hussain, G., Huang, J., Rasul, A., Anwar, H., Imran, A., Maqbool, J., Razzaq, A., Aziz, N., Makhdoom, E. ul H., Konuk, M., & Sun, T. (2019). Putative Roles of Plant-Derived Tannins in Neurodegenerative and Neuropsychiatry Disorders: An Updated Review. Molecules 2019, Vol. 24, Page 2213, 24(12), 2213. https://doi.org/10.3390/molecules24122213 DOI: https://doi.org/10.3390/molecules24122213
Inbar, O., Bar-Or, O., & Skinner, J. S. (1996). The Wingate Anaerobic Test. Human Kinetics. Retrieved from: https://books.google.co.il/books/about/The_Wingate_Anaerobic_Test.html?id=f2h3hWiNOOkC&redir_esc=y
Jaafaru, M. S., Nordin, N., Shaari, K., Rosli, R., & Abdull Razis, A. F. (2018). Isothiocyanate from Moringa oleifera seeds mitigates hydrogen peroxide-induced cytotoxicity and preserved morphological features of human neuronal cells. PLOS ONE, 13(5), e0196403. https://doi.org/10.1371/journal.pone.0196403 DOI: https://doi.org/10.1371/journal.pone.0196403
Jasaputra, D. K., Lucretia, T., Ray, H. R. D., Kwee, L., Gunawan, D., Edwinanto, L., Viona, S. I., Goenawan, H., Lesmana, R., & Gunadi, J. W. (2022). Moringa oleifera Leaves Extract Alters Exercise-Induced Cardiac Hypertrophy Adaptation. Pakistan Journal of Biological Sciences : PJBS, 25(3), 210-217. https://doi.org/10.3923/pjbs.2022.210.217 DOI: https://doi.org/10.3923/pjbs.2022.210.217
Kou, X., Li, B., Olayanju, J. B., Drake, J. M., & Chen, N. (2018). Nutraceutical or Pharmacological Potential of Moringa oleifera Lam. Nutrients 2018, Vol. 10, Page 343, 10(3), 343. https://doi.org/10.3390/nu10030343 DOI: https://doi.org/10.3390/nu10030343
Kushwaha, S., Chawla, P., & Kochhar, A. (2014). Effect of supplementation of drumstick (Moringa oleifera) and amaranth (Amaranthus tricolor) leaves powder on antioxidant profile and oxidative status among postmenopausal women. Journal of Food Science and Technology, 51(11), 3464-3469. https://doi.org/10.1007/s13197-012-0859-9 DOI: https://doi.org/10.1007/s13197-012-0859-9
Lamou, B., Taiwe, G. S., Hamadou, A., Abene, Houlray, J., Atour, M. M., & Tan, P. V. (2016a). Antioxidant and antifatigue properties of the aqueous extract of moringa oleifera in rats subjected to forced swimming endurance test. Oxidative Medicine and Cellular Longevity, 2016. https://doi.org/10.1155/2016/3517824 DOI: https://doi.org/10.1155/2016/3517824
Monera-Penduka, T. G., Maponga, C. C., Wolfe, A. R., Wiesner, L., Morse, G. D., & Nhachi, C. F. B. (2017). Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: A one sequence cross-over study. AIDS Research and Therapy, 14(1), 1-7. https://doi.org/10.1186/s12981-017-0140-4 DOI: https://doi.org/10.1186/s12981-017-0140-4
Olayinka, L. M., & O., B. C. (2017). Protective role of Moringa oleifera leaf-based diet on protein- energy malnutrition induced skeletal muscle degeneration. International Journal of Scientific Reports, 3(2), 54-62. https://doi.org/10.18203/issn.2454-2156.IntJSciRep20170358 DOI: https://doi.org/10.18203/issn.2454-2156.IntJSciRep20170358
Owens, F. S., Dada, O., Cyrus, J. W., Adedoyin, O. O., & Adunlin, G. (2020). The effects of Moringa oleifera on blood glucose levels: A scoping review of the literature. Complementary Therapies in Medicine, 50, 102362. https://doi.org/10.1016/j.ctim.2020.102362 DOI: https://doi.org/10.1016/j.ctim.2020.102362
Poulsen, N. B., Lambert, M. N. T., & Jeppesen, P. B. (2020). The Effect of Plant Derived Bioactive Compounds on Inflammation: A Systematic Review and Meta-Analysis. Molecular Nutrition & Food Research, 64(18), 2000473. https://doi.org/10.1002/mnfr.202000473 DOI: https://doi.org/10.1002/mnfr.202000473
Ray, H. R. D., Patriasih, R., Sulastri, A., & Lesmana, R. (2020). The potential of moringa oleifera on mitochondrial biogenesis through increases total oxphos units expression. Journal of Engineering Science and Technology, 15(6), 4214-4222. Retrived from: https://jestec.taylors.edu.my/Vol%2015%20issue%206%20December%202020/15_6_46.pdf
Sissoko, L., Diarra, N., Nientao, I., Stuart, B., Togola, A., Diallo, D., & Willcox, M. L. (2020). Moringa Oleifera leaf powder for type 2 diabetes: a pilot clinical trial. African Journal of Traditional, Complementary and Alternative Medicines, 17(2), 29-36. https://doi.org/10.21010/ajtcam.v17i2.3 DOI: https://doi.org/10.21010/ajtcam.v17i2.3
Stohs, S. J., & Hartman, M. J. (2015). Review of the Safety and Efficacy of Moringa oleifera. Phytotherapy Research, 29(6), 796-804. https://doi.org/10.1002/ptr.5325 DOI: https://doi.org/10.1002/ptr.5325
Taweerutchana, R., Lumlerdkij, N., Vannasaeng, S., Akarasereenont, P., & Sriwijitkamol, A. (2017). Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy-Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/6581390 DOI: https://doi.org/10.1155/2017/6581390
Thirupathi, A., & Pinho, R. A. (2018). Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles. Journal of Physiology and Biochemistry, 74(3), 359-367. https://doi.org/10.1007/s13105-018-0633-1 DOI: https://doi.org/10.1007/s13105-018-0633-1
Vehrs, P. R., George, J. D., Fellingham, G. W., Plowman, S. A., & Dustman-Allen, K. (2007). Submaximal Treadmill Exercise Test to Predict VO2max in Fit Adults. 11(2), 61-72. https://doi.org/10.1080/10913670701294047 DOI: https://doi.org/10.1080/10913670701294047