Exercise to reduce leptin on obesity A review
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Abstract
Obesity is a worldwide health problem associated with hypertension, diabetes, and cancer. An unhealthy and excessive diet, low physical activity, and a sedentary lifestyle are risk factors for obesity. Obesity causes adipokine dysfunction, one of which is leptin. Leptin is known to play a role in the regulation of metabolic homeostasis, especially in obesity. Hyperleptinemia in obesity is caused by leptin resistance, the result of excess energy intake and lack of physical activity or exercise, causing high levels of leptin in circulation. Regular physical exercise improves leptin signalling by regulating several proteins involved in signal transduction pathways in the hypothalamus. Physical exercise also reduces inflammation in the hypothalamus or acts as an anti-inflammatory. Stress on the endoplasmic reticulum is associated with hypothalamic inflammation and failure of insulin and leptin signalling. Improvement of leptin resistance is more effective in moderate and high-intensity aerobic exercise as well as resistance training carried out for >12 weeks with a frequency of exercise 3-4 times a week. Acute exercise and <12 weeks of exercise are not very effective in reducing leptin levels in obesity.
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References
Al-Amodi, H. S., Abdelbasit, N. A., Fatani, S. H., Babakr, A. T., & Mukhtar, M. M. (2018). The effect of obesity and components of metabolic syndrome on leptin levels in Saudi women. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 12(3), 357-364. https://doi.org/10.1016/j.dsx.2017.12.030 DOI: https://doi.org/10.1016/j.dsx.2017.12.030
Alizadeh, M., Shahrbanian, S., & Hackney, A. C. (2021). Comparison of the effects of 12 weeks of three types of resistance training (traditional, circular and interval) on the levels of neuregulin 4, adiponectin and leptin in non-athletic men with obesity. Archivos de Medicina Del Deporte, 38(6), 389-396. https://doi.org/10.18176/archmeddeporte.00066 DOI: https://doi.org/10.18176/archmeddeporte.00066
Arroyo-Johnson, C., & Mincey, K. D. (2016). Obesity Epidemiology Worldwide. In Gastroenterology Clinics of North America (Vol. 45, Issue 4, pp. 571-579). W.B. Saunders. https://doi.org/10.1016/j.gtc.2016.07.012 DOI: https://doi.org/10.1016/j.gtc.2016.07.012
Asle Mohammadi Zadeh, M., Kargarfard, M., Marandi, S. M., & Habibi, A. (2018). Diets along with interval training regimes improves inflammatory & anti-inflammatory condition in obesity with type 2 diabetes subjects. Journal of Diabetes and Metabolic Disorders, 17(2), 253-267. https://doi.org/10.1007/s40200-018-0368-0 DOI: https://doi.org/10.1007/s40200-018-0368-0
Ataeinosrat, A., Haghighi, M. M., Abednatanzi, H., Soltani, M., Ghanbari-Niaki, A., Nouri-Habashi, A., Amani-Shalamzari, S., Mossayebi, A., Khademosharie, M., Johnson, K. E., VanDusseldorp, T. A., Saeidi, A., & Zouhal, H. (2022). Effects of Three Different Modes of Resistance Training on Appetite Hormones in Males With Obesity. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.827335 DOI: https://doi.org/10.3389/fphys.2022.827335
Babaei, P., & Hoseini, R. (2022). Exercise training modulates adipokine dysregulations in metabolic syndrome. In Sports Medicine and Health Science (Vol. 4, Issue 1, pp. 18-28). KeAi Communications Co. https://doi.org/10.1016/j.smhs.2022.01.001 DOI: https://doi.org/10.1016/j.smhs.2022.01.001
Bharath, L. P., Choi, W. W., Cho, J. min, Skobodzinski, A. A., Wong, A., Sweeney, T. E., & Park, S. Y. (2018). Combined resistance and aerobic exercise training reduces insulin resistance and central adiposity in adolescent girls who are obese: randomized clinical trial. European Journal of Applied Physiology, 118(8), 1653-1660. https://doi.org/10.1007/s00421-018-3898-8 DOI: https://doi.org/10.1007/s00421-018-3898-8
Bouillon-Minois, J. B., Trousselard, M., Thivel, D., Benson, A. C., Schmidt, J., Moustafa, F., Bouvier, D., & Dutheil, F. (2021). Leptin as a biomarker of stress: A systematic review and meta-analysis. In Nutrients (Vol. 13, Issue 10). MDPI. https://doi.org/10.3390/nu13103350 DOI: https://doi.org/10.3390/nu13103350
Caballero, B. (2019). Humans against Obesity: Who Will Win? Advances in Nutrition, 10, S4-S9. https://doi.org/10.1093/advances/nmy055 DOI: https://doi.org/10.1093/advances/nmy055
Cinteza, E. E., & Cinteza, M. (2018). Biomarkers in obesity. In Revista Romana de Medicina de Laborator (Vol. 26, Issue 3, pp. 353-358). University of Medicine and Pharmacy Targu Mures. https://doi.org/10.2478/rrlm-2018-0027 DOI: https://doi.org/10.2478/rrlm-2018-0027
de Souza, D. C., Matos, V. A. F., dos Santos, V. O. A., Medeiros, I. F., Marinho, C. S. R., Nascimento, P. R. P., Dorneles, G. P., Peres, A., Müller, C. H., Krause, M., Costa, E. C., & Fayh, A. P. T. (2018). Effects of high-intensity interval and moderate-intensity continuous exercise on inflammatory, leptin, IgA, and lipid peroxidation responses in obese males. Frontiers in Physiology, 9(MAY). https://doi.org/10.3389/fphys.2018.00567 DOI: https://doi.org/10.3389/fphys.2018.00567
Dinari Ghozhdi, H., Heidarianpour, A., Keshvari, M., & Tavassoli, H. (2021). Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats. Diabetology and Metabolic Syndrome, 13(1). https://doi.org/10.1186/s13098-021-00676-x DOI: https://doi.org/10.1186/s13098-021-00676-x
Fedewa, M. V., Hathaway, E. D., Ward-Ritacco, C. L., Williams, T. D., & Dobbs, W. C. (2018). The Effect of Chronic Exercise Training on Leptin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. In Sports Medicine (Vol. 48, Issue 6, pp. 1437-1450). Springer International Publishing. https://doi.org/10.1007/s40279-018-0897-1 DOI: https://doi.org/10.1007/s40279-018-0897-1
Ghadge, A. A., & Khaire, A. A. (2019). Leptin as a predictive marker for metabolic syndrome. In Cytokine (Vol. 121). Academic Press. https://doi.org/10.1016/j.cyto.2019.154735 DOI: https://doi.org/10.1016/j.cyto.2019.154735
Gondim, O. S., De Camargo, V. T. N., Gutierrez, F. A., De Oliveira Martins, P. F., Passos, M. E. P., Momesso, C. M., Santos, V. C., Gorjão, R., Pithon-Curi, T. C., & Cury-Boaventura, M. F. (2015). Benefits of regular exercise on inflammatory and cardiovascular risk markers in normal weight, overweight and obese adults. PLoS ONE, 10(10). https://doi.org/10.1371/journal.pone.0140596 DOI: https://doi.org/10.1371/journal.pone.0140596
Gopalan, V., Yaligar, J., Michael, N., Kaur, K., Anantharaj, R., Verma, S. K., Sadananthan, S. A., Le, G. T. T., Goh, J., & Velan, S. S. (2021). A 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats. Bioscience Reports, 41(1). https://doi.org/10.1042/BSR20201707 DOI: https://doi.org/10.1042/BSR20201707
Gruzdeva, O., Borodkina, D., Uchasova, E., Dyleva, Y., & Barbarash, O. (2019). Leptin resistance: Underlying mechanisms and diagnosis. In Diabetes, Metabolic Syndrome and Obesity (Vol. 12, pp. 191-198). Dove Medical Press Ltd. https://doi.org/10.2147/DMSO.S182406 DOI: https://doi.org/10.2147/DMSO.S182406
Hales, C. M., Carroll, M. D., Fryar, C. D., & Ogden, C. L. (2017). Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-2018 Key findings Data from the National Health and Nutrition Examination Survey. Retrieved from: https://www.cdc.gov/nchs/products/index.htm
Hooshmand Moghadam, B., Golestani, F., Bagheri, R., Cheraghloo, N., Eskandari, M., Wong, A., Nordvall, M., Suzuki, K., & Pournemati, P. (2021). The effects of high-intensity interval training vs. Moderate-intensity continuous training on inflammatory markers, body composition, and physical fitness in overweight/obese survivors of breast cancer: A randomized controlled clinical trial. Cancers, 13(17). https://doi.org/10.3390/cancers13174386 DOI: https://doi.org/10.3390/cancers13174386
Hwang, J., Yoo, J. A., Yoon, H., Han, T., Yoon, J., An, S., Cho, J. Y., & Lee, J. (2021). The role of leptin in the association between obesity and psoriasis. Biomolecules and Therapeutics, 29(1), 11-21. https://doi.org/10.4062/biomolther.2020.054 DOI: https://doi.org/10.4062/biomolther.2020.054
Igel, L. I., Kumar, R. B., Saunders, K. H., & Aronne, L. J. (2017). Practical Use of Pharmacotherapy for Obesity. Gastroenterology, 152(7), 1765-1779. https://doi.org/10.1053/j.gastro.2016.12.049 DOI: https://doi.org/10.1053/j.gastro.2016.12.049
Iikuni, N., Kwan Lam, Q., Lu, L., Matarese, G., & Cava, A. (2008). Leptin and Inflammation. Current Immunology Reviews, 4(2), 70-79. https://doi.org/10.2174/157339508784325046 DOI: https://doi.org/10.2174/157339508784325046
Izquierdo, A. G., Crujeiras, A. B., Casanueva, F. F., & Carreira, M. C. (2019). Leptin, obesity, and leptin resistance: where are we 25 years later? In Nutrients (Vol. 11, Issue 11). MDPI AG. https://doi.org/10.3390/nu11112704 DOI: https://doi.org/10.3390/nu11112704
Jafari-Sfidvajani, S. J., Jafari, F., & Soltani, S. (2020). Vitamin D supplementation does not affect serum leptin and adiponectin levels in adults: A systematic review and meta-analysis of randomised controlled trials. Critical Comments in Biomedicine. https://doi.org/10.18502/ccb.v1i2.4029 DOI: https://doi.org/10.18502/ccb.v1i2.4029
Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., Loria, C. M., Millen, B. E., Nonas, C. A., Pi-Sunyer, F. X., Stevens, J., Stevens, V. J., Wadden, T. A., Wolfe, B. M., & Yanovski, S. Z. (2014). 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of cardiology/American Heart Association task force on practice guidelines and the obesity society. In Circulation (Vol. 129, Issue 25 SUPPL. 1). Lippincott Williams and Wilkins. https://doi.org/10.1161/01.cir.0000437739.71477.ee DOI: https://doi.org/10.1161/01.cir.0000437739.71477.ee
Kang, S., Kim, K. B., & Shin, K. O. (2013). Exercise training improve leptin sensitivity in peripheral tissue of obese rats. Biochemical and Biophysical Research Communications, 435(3), 454-459. https://doi.org/10.1016/j.bbrc.2013.05.007 DOI: https://doi.org/10.1016/j.bbrc.2013.05.007
Kemenkes RI.(2018). Laporan Nasional Riskesdas 2018. Kementerian Kesehatan RI. Jakarta.
Kim, D., Hou, W., Wang, F., & Arcan, C. (2019). Factors affecting obesity and waist circumference among US adults. Preventing Chronic Disease, 16(1). https://doi.org/10.5888/pcd16.180220 DOI: https://doi.org/10.5888/pcd16.180220
Kong, Z., Sun, S., Liu, M., & Shi, Q. (2016). Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women. Journal of Diabetes Research, 2016. https://doi.org/10.1155/2016/4073618 DOI: https://doi.org/10.1155/2016/4073618
La Cava, A. (2017). Leptin in inflammation and autoimmunity. In Cytokine (Vol. 98, pp. 51-58). Academic Press. https://doi.org/10.1016/j.cyto.2016.10.011 DOI: https://doi.org/10.1016/j.cyto.2016.10.011
Landecho, M. F., Tuero, C., Valentí, V., Bilbao, I., de la Higuera, M., & Frühbeck, G. (2019). Relevance of leptin and other adipokines in obesity-associated cardiovascular risk. In Nutrients (Vol. 11, Issue 11). MDPI AG. https://doi.org/10.3390/nu11112664 DOI: https://doi.org/10.3390/nu11112664
Li, C., Lyu, S., & Zhang, J. (2022). Effects of Aerobic Exercise on the Serum Leptin Level and Heart Rate Variability in the Obese Girl Children. Computational Intelligence and Neuroscience, 2022. https://doi.org/10.1155/2022/2298994 DOI: https://doi.org/10.1155/2022/2298994
Li, S., Kim, J. Y., & Sim, Y. J. (2020). Effects of 10-week combined training on lipid metabolic regulatory hormones and metabolic syndrome index according to exercise dose in obese male college students. Journal of Exercise Rehabilitation, 16(1), 101-107. https://doi.org/10.12965/jer.2040008.004 DOI: https://doi.org/10.12965/jer.2040008.004
Many, G., Hurtado, M.-E., Tanner, C., Houmard, J., Gordish-Dressman, H., Park, J.-J., Uwaifo, G., Kraus, W., Hagberg, J., & Hoffman, E. (2013). Moderate-Intensity Aerobic Training Program Improves Insulin Sensitivity and Inflammatory Markers in a Pilot Study of Morbidly Obese Minority Teens. In Pediatric Exercise Science (Vol. 25). https://doi.org/10.1123/pes.25.1.12 DOI: https://doi.org/10.1123/pes.25.1.12
Martins, C., Kulseng, B., Rehfeld, J. F., King, N. A., & Blundell, J. E. (2013). Effect of chronic exercise on appetite control in overweight and obese individuals. Medicine and Science in Sports and Exercise, 45(5), 805-812. https://doi.org/10.1249/MSS.0b013e31827d1618 DOI: https://doi.org/10.1249/MSS.0b013e31827d1618
Muhammad, H. F. L., Pahdarina, D., Zahara, N. P., Nugraheni, F., Hanny, T. A., Ermamilia, A., & Huriyati, E. (2021). Diet or exercise: The role of diet and/or exercise on changes of pro-inflammatory markers during a weight loss program in adult women with overweight. Clinical Nutrition ESPEN, 44, 337-341. https://doi.org/10.1016/j.clnesp.2021.05.022 DOI: https://doi.org/10.1016/j.clnesp.2021.05.022
Nunes, P. R. P., Martins, F. M., Souza, A. P., Carneiro, M. A. S., Orsatti, C. L., Michelin, M. A., Murta, E. F. C., De Oliveira, E. P., & Orsatti, F. L. (2019). Effect of high-intensity interval training on body composition and inflammatory markers in obese postmenopausal women: A randomized controlled trial. Menopause, 26(3), 256-264. https://doi.org/10.1097/GME.0000000000001207 DOI: https://doi.org/10.1097/GME.0000000000001207
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R. (2021). Leptin and Obesity: Role and Clinical Implication. In Frontiers in Endocrinology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fendo.2021.585887 DOI: https://doi.org/10.3389/fendo.2021.585887
Osegbe I, Okpara H, Azinge E. (2016). Relationship between serum leptin and insulin resistance among obese Nigerian women. Ann Afr Med. Jan-Mar;15(1):14-9. https://doi.org/10.4103/1596-3519.158524 DOI: https://doi.org/10.4103/1596-3519.158524
Peng, J., Yin, L., & Wang, X. (2021). Central and peripheral leptin resistance in obesity and improvements of exercise. In Hormones and Behavior (Vol. 133). Academic Press Inc. https://doi.org/10.1016/j.yhbeh.2021.105006 DOI: https://doi.org/10.1016/j.yhbeh.2021.105006
Perakakis, N., Farr, O. M., & Mantzoros, C. S. (2021). Leptin in Leanness and Obesity: JACC State-of-the-Art Review. In Journal of the American College of Cardiology (Vol. 77, Issue 6, pp. 745-760). Elsevier Inc. https://doi.org/10.1016/j.jacc.2020.11.069 DOI: https://doi.org/10.1016/j.jacc.2020.11.069
Rodrigues, K. C. da C., Pereira, R. M., de Campos, T. D. P., de Moura, R. F., da Silva, A. S. R., Cintra, D. E., Ropelle, E. R., Pauli, J. R., de Araújo, M. B., & de Moura, L. P. (2018). The role of physical exercise to improve the browning of white adipose tissue via POMC neurons. In Frontiers in Cellular Neuroscience (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fncel.2018.00088 DOI: https://doi.org/10.3389/fncel.2018.00088
Rostás, I., Pótó, L., Mátrai, P., Hegyi, P., Tenk, J., Garami, A., Illés, A., Solymár, M., Pétervári, E., Szűcs, Á., Párniczky, A., Pécsi, D., Rumbus, Z., Zsiborás, C., Füredi, N., & Balaskó, M. (2017). In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis. PLoS ONE, 12(8). https://doi.org/10.1371/journal.pone.0182801 DOI: https://doi.org/10.1371/journal.pone.0182801
Sáinz, N., Barrenetxe, J., Moreno-Aliaga, M. J., & Martínez, J. A. (2015). Leptin resistance and diet-induced obesity: Central and peripheral actions of leptin. In Metabolism: Clinical and Experimental (Vol. 64, Issue 1, pp. 35-46). W.B. Saunders. https://doi.org/10.1016/j.metabol.2014.10.015 DOI: https://doi.org/10.1016/j.metabol.2014.10.015
Sinorita, H., Asdie, R. H., Pramono, R. B., Purnama, L. B., & Asdie, A. H. (2009). Leptin, Adiponectin and Resistin Concentration in Obesity Class I and II at Sardjito Hospital Yogyakarta.
Tremblay, M. S., LeBlanc, A. G., Janssen, I., Kho, M. E., Hicks, A., Murumets, K., Colley, R. C., & Duggan, M. (2011). Canadian sedentary behaviour guidelines for children and youth. In Applied Physiology, Nutrition and Metabolism (Vol. 36, Issue 1, pp. 59-64). https://doi.org/10.1139/H11-012 DOI: https://doi.org/10.1139/H11-012
Vardar, S. A., Karaca, A., Güldiken, S., Palabıyık, O., Süt, N., & Demir, A. M. (2018). High-intensity interval training acutely alters plasma adipokine levels in young overweight/obese women. Archives of Physiology and Biochemistry, 124(2), 149-155. https://doi.org/10.1080/13813455.2017.1369998 DOI: https://doi.org/10.1080/13813455.2017.1369998
WHO. (2021). Obesity and Overweight. Available from : https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (Access: September 8, 2022)
Yu, N., Ruan, Y., Gao, X., & Sun, J. (2017). Systematic Review and Meta-Analysis of Randomized, Controlled Trials on the Effect of Exercise on Serum Leptin and Adiponectin in Overweight and Obese Individuals. Hormone and Metabolic Research, 49(3), 164-173. https://doi.org/10.1055/s-0042-121605 DOI: https://doi.org/10.1055/s-0042-121605
Zhang, Y., & Chua, S. (2018). Leptin function and regulation. Comprehensive Physiology, 8(1), 351-369. https://doi.org/10.1002/cphy.c160041 DOI: https://doi.org/10.1002/cphy.c160041
Zhao, S., Kusminski, C. M., Elmquist, J. K., & Scherer, P. E. (2020). Leptin: Less is more. Diabetes, 69(5), 823-829. https://doi.org/10.2337/dbi19-0018 DOI: https://doi.org/10.2337/dbi19-0018